Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery
نویسندگان
چکیده
منابع مشابه
Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery.
Impressive progress in genome sequencing, protein expression and high-throughput crystallography and NMR has radically transformed the opportunities to use protein three-dimensional structures to accelerate drug discovery, but the quantity and complexity of the data have ensured a central place for informatics. Structural biology and bioinformatics have assisted in lead optimization and target ...
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Structure determination has already proven useful for lead optimization and direct drug design. The number of high-resolution structures available in public databases today exceeds 30,000 and will definitely aid in structure-based drug design. Structural genomics approaches covering whole genomes, topologically similar proteins or gene families are great assets for further progress in the devel...
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Chapter Overview As biomedical research and healthcare continue to progress in the genomic/post genomic era a number of important challenges and opportunities exist in the broad area of biomedical informatics. In the context of this chapter we define bioinformatics as the field that focuses on information, data, and knowledge in the context of biological and biomedical research. The key challen...
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ژورنال
عنوان ژورنال: Emerging Microbes & Infections
سال: 2019
ISSN: 2222-1751
DOI: 10.1080/22221751.2018.1561158